Animals and plants are metaorganisms and associate with microbes that affect their physiology, stress tolerance, and fitness. Here the hypothesis that alteration of the microbiome may constitute a fast‐response mechanism to environmental change is examined. This is supported by recent reciprocal transplant experiments with reef corals, which have shown that their microbiome adapts to thermally variable habitats and changes over time when transplanted into different environments. Further, inoculation of corals with beneficial bacteria increases their stress tolerance. But corals differ in (...) their ability to flexibly associate with different bacteria. How scales of microbiome flexibility may reflect different metaorganism adaptation mechanisms is discussed and future directions for research are pinpointed. It is posited that microbiome flexibility is a broad phenomenon that contributes to the ability of organisms to respond to environmental change. Importantly, adapting with microbial help may provide an alternate route to organismal adaptation that facilitates rapid responses. (shrink)

Graphical AbstractIn article number 2000004 by Christian R. Voolstra and Maren Ziegler, microbiome flexibility, i.e., the potential for dynamic restructuring of the host microbiome, as a fast-response mechanism to environmental change is examined. How scales of microbiome flexibility may reflect different metaorganism adaptation mechanisms and future research directions are discussed. Adapting with microbial help may provide an alternate route to organismal adaptation that facilitates rapid responses. Art designer: Ivan Gromicho, King Abdullah University of Science and Technology (KAUST).